Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)

Diethylstilbestrol (DES) is a synthetic estrogen and proven human teratogen and carcinogen reported to act via the estrogen receptor α (ERα). Since the endogenous ERα ligand 17β-estradiol (E2) does not show these adverse effects to a similar extent, we hypothesized that DES’ interaction with the ERα...

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Detalhes bibliográficos
Publicado no:Cell Biol Toxicol
Main Authors: Adam, Aziza Hussein Bakheit, de Haan, Laura H. J., Estruch, Ignacio Miro, Hooiveld, Guido J. E. J., Louisse, Jochem, Rietjens, Ivonne M. C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505815/
https://ncbi.nlm.nih.gov/pubmed/32088792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-020-09516-6
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