Potential COVID-19 papain-like protease PL(pro) inhibitors: repurposing FDA-approved drugs

Using the crystal structure of SARS-CoV-2 papain-like protease (PL(pro)) as a template, we developed a pharmacophore model of functional centers of the PL(pro) inhibitor-binding pocket. With this model, we conducted data mining of the conformational database of FDA-approved drugs. This search identi...

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Bibliographic Details
Published in:PeerJ
Main Authors: Kouznetsova, Valentina L., Zhang, Aidan, Tatineni, Mahidhar, Miller, Mark A., Tsigelny, Igor F.
Format: Artigo
Language:Inglês
Published: PeerJ Inc. 2020
Subjects:
Bioinformatics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505060/
https://ncbi.nlm.nih.gov/pubmed/32999768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9965
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