Safety, Tolerability, and Pharmacokinetics of Crenezumab in Patients with Mild-to-Moderate Alzheimer’s Disease Treated with Escalating Doses for up to 133 Weeks

BACKGROUND: Crenezumab is a fully humanized, monoclonal anti-amyloid-β immunoglobulin G4 antibody. OBJECTIVE: This Phase Ib study (NCT02353598) evaluated the safety, tolerability, and pharmacokinetics of crenezumabat doses of ≤120 mg/kg administered intravenously every 4 weeks (q4w). Immunogenicity...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Guthrie, Heather, Honig, Lawrence S., Lin, Helen, Sink, Kaycee M., Blondeau, Kathleen, Quartino, Angelica, Dolton, Michael, Carrasco-Triguero, Montserrat, Lian, Qinshu, Bittner, Tobias, Clayton, David, Smith, Jillian, Ostrowitzki, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505005/
https://ncbi.nlm.nih.gov/pubmed/32568196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200134
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