Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver

Heavy alcohol drinking dysregulates lipid metabolism, promoting hepatic steatosis – the first stage of alcohol-related liver disease (ALD). The molecular circadian clock plays a major role in synchronizing daily rhythms in behavior and metabolism and clock disruption can cause pathology, including l...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Valcin, Jennifer A., Udoh, Uduak S., Swain, Telisha M., Andringa, Kelly K., Patel, Chirag R., Al Diffalha, Sameer, Baker, Paul R. S., Gamble, Karen L., Bailey, Shannon M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7504911/
https://ncbi.nlm.nih.gov/pubmed/33013449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.01048
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