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Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against different cellular stresses, such as accumulation of misfolded proteins. Unlike g...
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| Publié dans: | Int J Mol Sci |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7504470/ https://ncbi.nlm.nih.gov/pubmed/32846985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21176088 |
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