Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance

BACKGROUND: Insulin resistance in visceral adipose tissue (VAT), skeletal muscle and liver is a prominent feature of most patients with obesity. How this association arises remains poorly understood. The objective of this study was to demonstrate that the decrease in insulin receptor (INSR) expressi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EBioMedicine
Päätekijät: Arcidiacono, Biagio, Chiefari, Eusebio, Foryst-Ludwig, Anna, Currò, Giuseppe, Navarra, Giuseppe, Brunetti, Francesco S., Mirabelli, Maria, Corigliano, Domenica M., Kintscher, Ulrich, Britti, Domenico, Mollace, Vincenzo, Foti, Daniela P., Goldfine, Ira D., Brunetti, Antonio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2020
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502675/
https://ncbi.nlm.nih.gov/pubmed/32739259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102912
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