Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis

BACKGROUND: Inflammation plays an important role in the development of cardiovascular disease (CVD). Patients with chronic inflammation diseases have high levels of inflammation and early fatal myocardial infarction due to early, unstable coronary plaques. Cholesterol crystals (CC) play a key role i...

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Publicado en:EBioMedicine
Autores principales: Baumer, Yvonne, Dey, Amit K., Gutierrez-Huerta, Cristhian A., Khalil, Noor O., Sekine, Yusuke, Sanda, Gregory E., Zhuang, Jie, Saxena, Ankit, Stempinski, Erin, Elnabawi, Youssef A., Dagur, Pradeep K., Ng, Qimin, Teague, Heather L., Keel, Andrew, Rodante, Justin A., Boisvert, William A., Tsoi, Lam C., Gudjonsson, Johann E., Bleck, Christopher K.E., Chen, Marcus Y., Bluemke, David A., Gelfand, Joel M., Schwartz, Daniella M., Kruth, Howard S., Powell-Wiley, Tiffany M., Playford, Martin P., Mehta, Nehal N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502673/
https://ncbi.nlm.nih.gov/pubmed/32646751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102876
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