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Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections

BACKGROUND: Chronic and recurrent bacterial diseases are recalcitrant to treatment due to the ability of the causative agents to establish biofilms, thus development of means to prevent or resolve these structures are greatly needed. Our approach targets the DNABII family of bacterial DNA-binding pr...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Novotny, Laura A., Goodman, Steven D., Bakaletz, Lauren O.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502671/
https://ncbi.nlm.nih.gov/pubmed/32651162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102867
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