An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis

The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory serine 472 phosphorylation site. Whereas the function of full-length Akt3 isoform (Akt3/+S472) is well-characterized, that of Akt3/-S472 isofor...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cancer Res
Autors principals: Suyama, Kimita, Yao, Jiahong, Liang, Huizhi, Benard, Outhiriaradjou, Loudig, Olivier, Amgalan, Dulguun, McKimpson, Wendy M., Phillips, Greg R., Segall, Jeffrey, Wang, Yihong, Fineberg, Susan, Norton, Larry, Kitsis, Richard N., Hazan, Rachel B.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501878/
https://ncbi.nlm.nih.gov/pubmed/29038347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1462
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars