Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells

S100P, a calcium-binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to identify, synthesize and evaluate novel small molecules with the potential to sele...

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Publicado en:Eur J Med Chem
Autores principales: Camara, Ramatoulie, Ogbeni, Deborah, Gerstmann, Lisa, Ostovar, Mehrnoosh, Hurer, Ellie, Scott, Mark, Mahmoud, Nasir G., Radon, Tomasz, Crnogorac-Jurcevic, Tatjana, Patel, Pryank, Mackenzie, Louise S., Chau, David Y.S., Kirton, Stewart B., Rossiter, Sharon
Formato: Artigo
Lenguaje:Inglês
Publicado: Editions Scientifiques Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501730/
https://ncbi.nlm.nih.gov/pubmed/32707527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112621
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