Tumor Microenvironment composition and severe cytokine release syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel

PURPOSE: One of the challenges of adoptive T cell therapy is the development of immune mediated toxicities including cytokine release syndrome (CRS) and neurotoxicity (NT). We aimed to identify factors that place patients at high risk of severe toxicity or treatment related death in a cohort of 75 p...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Faramand, Rawan, Jain, Michael, Staedtke, Verena, Kotani, Hiroshi, Bai, Renyuan, Reid, Kayla, Lee, Sae Bom, Spitler, Kristen, Wang, Xuefeng, Cao, Biwei, Pinilla, Javier, Lazaryan, Aleksander, Khimani, Farhad, Shah, Bijal, Chavez, Julio C., Nishihori, Taiga, Mishra, Asmita, Mullinax, John, Gonzalez, Ricardo, Hussaini, Mohammad, Dam, Marian, Brandjes, Brigett D, Bachmeier, Christina A, Anasetti, Claudio, Locke, Frederick L., Davila, Marco L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501265/
https://ncbi.nlm.nih.gov/pubmed/32669372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1434
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