Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cance

PURPOSE: Plasma genotyping may identify mutations in potentially “actionable” cancer genes, such as BRCA1/2, but their clinical significance is not well defined. We evaluated the characteristics of somatically acquired BRCA1/2 mutations in patients with MBC. METHODS: Patients with MBC undergoing rou...

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Udgivet i:Clin Cancer Res
Main Authors: Vidula, Neelima, Dubash, Taronish, Lawrence, Michael S., Simoneau, Antoine, Niemierko, Andrzej, Blouch, Erica, Nagy, Becky, Roh, Whijae, Chirn, Brian, Reeves, Brittany A., Malvarosa, Giuliana, Lennerz, Jochen, Isakoff, Steven J., Juric, Dejan, Micalizzi, Douglas, Wander, Seth, Spring, Laura, Moy, Beverly, Shannon, Kristen, Younger, Jerry, Lanman, Richard, Toner, Mehmet, Iafrate, A. John, Getz, Gad, Zou, Lee, Ellisen, Leif W., Maheswaran, Shyamala, Haber, Daniel A., Bardia, Aditya
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501190/
https://ncbi.nlm.nih.gov/pubmed/32571788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0638
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