Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cance

PURPOSE: Plasma genotyping may identify mutations in potentially “actionable” cancer genes, such as BRCA1/2, but their clinical significance is not well defined. We evaluated the characteristics of somatically acquired BRCA1/2 mutations in patients with MBC. METHODS: Patients with MBC undergoing rou...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Vidula, Neelima, Dubash, Taronish, Lawrence, Michael S., Simoneau, Antoine, Niemierko, Andrzej, Blouch, Erica, Nagy, Becky, Roh, Whijae, Chirn, Brian, Reeves, Brittany A., Malvarosa, Giuliana, Lennerz, Jochen, Isakoff, Steven J., Juric, Dejan, Micalizzi, Douglas, Wander, Seth, Spring, Laura, Moy, Beverly, Shannon, Kristen, Younger, Jerry, Lanman, Richard, Toner, Mehmet, Iafrate, A. John, Getz, Gad, Zou, Lee, Ellisen, Leif W., Maheswaran, Shyamala, Haber, Daniel A., Bardia, Aditya
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501190/
https://ncbi.nlm.nih.gov/pubmed/32571788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0638
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