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pH dependence of the Slc4a11-mediated H(+) conductance is influenced by intracellular lysine residues and modified by disease-linked mutations

SLC4A11 is the only member of the SLC4 family that transports protons rather than bicarbonate. SLC4A11 is expressed in corneal endothelial cells, and its mutation causes corneal endothelial dystrophy, although the mechanism of pathogenesis is unknown. We previously demonstrated that the magnitude of...

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Pubblicato in:Am J Physiol Cell Physiol
Autori principali: Quade, Bianca N., Marshall, Aniko, Parker, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500215/
https://ncbi.nlm.nih.gov/pubmed/32520610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00128.2020
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