Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia

PURPOSE: Polymorphisms at the caveolin-1/2 locus are associated with glaucoma and IOP risk and deletion of caveolin-1 (Cav1) in mice elevates IOP and reduces outflow facility. However, the specific location/cell type responsible for Cav1-dependent regulation of IOP is unclear. We hypothesized that e...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: De Ieso, Michael L., Gurley, Jami M., McClellan, Mark E., Gu, Xiaowu, Navarro, Iris, Li, Guorong, Gomez-Caraballo, Maria, Enyong, Eric, Stamer, W. Daniel, Elliott, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Physiology and Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500130/
https://ncbi.nlm.nih.gov/pubmed/32940661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.11.32
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