Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism

Metastatic melanoma cells overexpressing gap junctions were assayed for their ability to propagate cell death by a novel combination therapy that generates reactive oxygen species (ROS) by both 1) non-thermal plasma (NTP) and 2) tirapazamine (TPZ) under hypoxic conditions. Results demonstrate additi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bagati, Archis, Hutcherson, Timothy C., Koch, Zethan, Pechette, Joseph, Dianat, Hossein, Higley, Cory, Chiu, Lisa, Song, Yesul, Shah, Jay, Chazen, Elana, Nicolais, Andrew, Casey, Peter, Thompson, Kyle, Burke, Kevin, Nikiforov, Mikhail A., Zirnheld, Jennifer, Zucker, Shoshanna N.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500108/
https://ncbi.nlm.nih.gov/pubmed/32973969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27732
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