Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from advanced ccRCC patients enrolled in prospective clinical trials of treatment with PD-1 bl...

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Библиографические подробности
Опубликовано в: :Nat Med
Главные авторы: Braun, David A., Hou, Yue, Bakouny, Ziad, Ficial, Miriam, Angelo, Miriam Sant’, Forman, Juliet, Ross-Macdonald, Petra, Berger, Ashton C., Jegede, Opeyemi A., Elagina, Liudmilla, Steinharter, John, Sun, Maxine, Wind-Rotolo, Megan, Pignon, Jean-Christophe, Cherniack, Andrew C., Lichtenstein, Lee, Neuberg, Donna, Catalano, Paul, Freeman, Gordon J., Sharpe, Arlene H., McDermott, David F., Van Allen, Eliezer M., Signoretti, Sabina, Wu, Catherine J., Shukla, Sachet A., Choueiri, Toni K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499153/
https://ncbi.nlm.nih.gov/pubmed/32472114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0839-y
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