Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease

Anti-CD20-mediated B-cell depletion effectively reduces acute multiple sclerosis (MS) flares. Recent data shows that antibody-mediated extinction of B cells as a lasting immune suppression, harbors the risk of developing humoral deficiencies over time. Accordingly, more selective, durable and revers...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Torke, Sebastian, Pretzsch, Roxanne, Häusler, Darius, Haselmayer, Philipp, Grenningloh, Roland, Boschert, Ursula, Brück, Wolfgang, Weber, Martin S.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498502/
https://ncbi.nlm.nih.gov/pubmed/32761407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02204-z
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