Impact of single-heterozygous UGT1A1 on the clinical outcomes of irinotecan monotherapy after fluoropyrimidine and platinum-based combination therapy for gastric cancer: a multicenter retrospective study

BACKGROUND: It is unclear whether the UGT1A1 status, single heterozygous (SH) or wild type (WT), is associated with the efficacy and toxicity of irinotecan monotherapy in advanced gastric cancer (AGC). We investigated the association between clinical outcomes (efficacy and safety) and UGT1A1 status...

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Detalhes bibliográficos
Publicado no:Int J Clin Oncol
Main Authors: Nakano, Shintaro, Yuki, Satoshi, Kawamoto, Yasuyuki, Nakatsumi, Hiroshi, Ando, Takayuki, Kajiura, Shinya, Yoshikawa, Ayumu, Harada, Kazuaki, Hatanaka, Kazuteru, Tanimoto, Aya, Ishiguro, Atsushi, Honda, Takuya, Dazai, Masayoshi, Sasaki, Takahide, Sakamoto, Naoya, Komatsu, Yoshito
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498487/
https://ncbi.nlm.nih.gov/pubmed/32666389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10147-020-01720-y
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