Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma

BI 836826 is a chimeric immunoglobulin G1 antibody targeting CD37, a tetraspanin transmembrane protein predominantly expressed on normal and malignant B cells. This phase I, open-label study used a modified 3 + 3 design to evaluate the safety, maximum tolerated dose (MTD), pharmacokinetics, and prel...

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Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Kroschinsky, Frank, Middeke, Jan Moritz, Janz, Martin, Lenz, Georg, Witzens-Harig, Mathias, Bouabdallah, Reda, La Rosée, Paul, Viardot, Andreas, Salles, Gilles, Kim, Seok Jin, Kim, Tae Min, Ottmann, Oliver, Chromik, Joerg, Quinson, Anne-Marie, von Wangenheim, Ute, Burkard, Ute, Berk, Andreas, Schmitz, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Phase I Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497676/
https://ncbi.nlm.nih.gov/pubmed/32172489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-020-00916-3
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