Atroposelective Synthesis of Axially Chiral N‐Arylpyrroles by Chiral‐at‐Rhodium Catalysis

A transformation of fluxional into configurationally stable axially chiral N‐arylpyrroles was achieved with a highly atroposelective electrophilic aromatic substitution catalyzed by a chiral‐at‐metal rhodium Lewis acid. Specifically, N‐arylpyrroles were alkylated with N‐acryloyl‐1H‐pyrazole electrop...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Ye, Chen‐Xi, Chen, Shuming, Han, Feng, Xie, Xiulan, Ivlev, Sergei, Houk, K. N., Meggers, Eric
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496906/
https://ncbi.nlm.nih.gov/pubmed/32488954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004799
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