Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8(+) T cells

Adoptive T cell transfer therapy induces objective responses in patients with advanced malignancies. Despite these results, some individuals do not respond due to the generation of terminally differentiated T cells during the expansion protocol. As the gamma and delta catalytic subunits in the PI3K...

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Veröffentlicht in:Eur J Immunol
Hauptverfasser: Dwyer, Connor J., Arhontoulis, Dimitrios C., Rangel Rivera, Guillermo O, Knochelmann, Hannah M., Smith, Aubrey S., Wyatt, Megan M., Rubinstein, Mark P., Atkinson, Carl, Thaxton, Jessica E., Neskey, David M., Paulos, Chrystal M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Tumor immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496332/
https://ncbi.nlm.nih.gov/pubmed/32383488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948455
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