Andecaliximab/GS-5745 Alone and Combined with mFOLFOX6 in Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Results from a Phase I Study

PURPOSE: Matrix metalloproteinase-9 (MMP9) is implicated in protumorigenic processes. Andecaliximab (GS-5745, a monoclonal antibody targeting MMP9) was evaluated as monotherapy and in combination with mFOLFOX6. PATIENTS AND METHODS: Three dosages of andecaliximab monotherapy [200, 600, and 1800 mg i...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Shah, Manish A., Starodub, Alexander, Sharma, Sunil, Berlin, Jordan, Patel, Manish, Wainberg, Zev A., Chaves, Jorge, Gordon, Michael, Windsor, Kevin, Brachmann, Carrie Baker, Huang, Xi, Vosganian, Greg, Maltzman, Julia D., Smith, Victoria, Silverman, Jeffrey A., Lenz, Heinz-Josef, Bendell, Johanna C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496223/
https://ncbi.nlm.nih.gov/pubmed/29691300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2469
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