Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines

It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mouse models, a reduced secretion of cytokines has bee...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Spitzer, Philipp, Walter, Matthias, Göth, Caroline, Oberstein, Timo Jan, Linning, Philipp, Knölker, Hans-Joachim, Kornhuber, Johannes, Maler, Juan Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494750/
https://ncbi.nlm.nih.gov/pubmed/33013850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01967
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