Neonatal isoflurane anesthesia or disruption of postsynaptic density-95 protein interactions change dendritic spine densities and cognitive function in juvenile mice

BACKGROUND: Experimental evidence shows postnatal exposure to anesthesia negatively affects brain development. The PDZ2 domain, mediating protein-protein interactions of the postsynaptic density-95 protein, serves as a molecular target for several inhaled anesthetics. We hypothesize that early postn...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Schaefer, Michele L., Perez, Patric J., Wang, Meina, Gray, Christy, Krall, Caroline, Sun, Xiaoning, Hunter, Elizabeth, Skinner, John, Johns, Roger A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494580/
https://ncbi.nlm.nih.gov/pubmed/32773681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003482
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