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Structure-based inhibitors targeting the alpha-helical domain of the Spiroplasma melliferum histone-like HU protein
Here we report bisphenol derivatives of fluorene (BDFs) as a new type of chemical probes targeting a histone-like HU protein, a global regulator of bacterial nucleoids, via its dimerization interface perturbation. BDFs were identified by virtual screening and molecular docking that targeted the core...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7493962/ https://ncbi.nlm.nih.gov/pubmed/32934267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72113-4 |
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