Robust ω-Transaminases by Computational Stabilization of the Subunit Interface

[Image: see text] Transaminases are attractive catalysts for the production of enantiopure amines. However, the poor stability of these enzymes often limits their application in biocatalysis. Here, we used a framework for enzyme stability engineering by computational library design (FRESCO) to stabi...

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Veröffentlicht in:ACS Catal
Hauptverfasser: Meng, Qinglong, Capra, Nikolas, Palacio, Cyntia M., Lanfranchi, Elisa, Otzen, Marleen, van Schie, Luc Z., Rozeboom, Henriëtte J., Thunnissen, Andy-Mark W. H., Wijma, Hein J., Janssen, Dick B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493286/
https://ncbi.nlm.nih.gov/pubmed/32953233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b05223
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