Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3′ end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA, causing transformation of human cells in vitro....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:iScience
मुख्य लेखकों: Chen, Danqi, Chen, Qiao Yi, Wang, Zhenjia, Zhu, Yusha, Kluz, Thomas, Tan, Wuwei, Li, Jinquan, Wu, Feng, Fang, Lei, Zhang, Xiaoru, He, Rongquan, Shen, Steven, Sun, Hong, Zang, Chongzhi, Jin, Chunyuan, Costa, Max
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492993/
https://ncbi.nlm.nih.gov/pubmed/32920490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101518
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