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Overcoming Resistance to Drugs Targeting KRAS(G12C) Mutation

Activating KRAS mutations are present in 25% of human cancer. Although oncogenic Ras was deemed “undruggable” in the past, recent efforts led to the development of pharmacological inhibitors targeting the KRAS(G12C) mutant, which have shown promise in early clinical trials. The development of allele...

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Bibliografiska uppgifter
I publikationen:Innovation (Camb)
Huvudupphovsmän: Jiao, Delong, Yang, Shengyu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491749/
https://ncbi.nlm.nih.gov/pubmed/32939510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xinn.2020.100035
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