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Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells as an in vitro model of inflammation

COVID-19 has posed a significant threat to global health. Early data has revealed that IL-6, a key regulatory cytokine, plays an important role in the cytokine storm of COVID-19. Multiple trials are therefore looking at the effects of Tocilizumab, an IL-6 receptor antibody that inhibits IL-6 activit...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:bioRxiv
Päätekijät: Zarinsefat, Arya, Hartoularos, George, Chandran, Sindhu, Yee, Chun J., Vincenti, Flavio, Sarwal, Minnie M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7491509/
https://ncbi.nlm.nih.gov/pubmed/32935096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.11.281782
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