Capsaicin Is a Negative Allosteric Modulator of the 5-HT(3) Receptor

In this study, effects of capsaicin, an active ingredient of the capsicum plant, were investigated on human 5-hydroxytryptamine type 3 (5-HT(3)) receptors. Capsaicin reversibly inhibited serotonin (5-HT)-induced currents recorded by two-electrode voltage clamp method in Xenopus oocytes. The inhibiti...

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Vydáno v:Front Pharmacol
Hlavní autoři: Nebrisi, Eslam El, Prytkova, Tatiana, Lorke, Dietrich Ernst, Howarth, Luke, Alzaabi, Asma Hassan, Yang, Keun-Hang Susan, Howarth, Frank C., Oz, Murat
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490547/
https://ncbi.nlm.nih.gov/pubmed/32982728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01274
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