Multi-omic studies on missense PLG variants in families with otitis media

Otitis media (OM), a very common disease in young children, can result in hearing loss. In order to potentially replicate previously reported associations between OM and PLG, exome and Sanger sequencing, RNA-sequencing of saliva and middle ear samples, 16S rRNA sequencing, molecular modeling, and st...

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Publicat a:Sci Rep
Autors principals: Bootpetch, Tori C., Hafrén, Lena, Elling, Christina L., Baschal, Erin E., Manichaikul, Ani W., Pine, Harold S., Szeremeta, Wasyl, Scholes, Melissa A., Cass, Stephen P., Larson, Eric D., Chan, Kenny H., Ishaq, Rafaqat, Prager, Jeremy D., Shaikh, Rehan S., Gubbels, Samuel P., Yousaf, Ayesha, Wine, Todd M., Bamshad, Michael J., Yoon, Patricia J., Jenkins, Herman A., Nickerson, Deborah A., Streubel, Sven-Olrik, Friedman, Norman R., Frank, Daniel N., Einarsdottir, Elisabet, Kere, Juha, Riazuddin, Saima, Daly, Kathleen A., Leal, Suzanne M., Ryan, Allen F., Mattila, Petri S., Ahmed, Zubair M., Sale, Michele M., Chonmaitree, Tasnee, Santos-Cortez, Regie Lyn P.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490366/
https://ncbi.nlm.nih.gov/pubmed/32929111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70498-w
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