Reversing binding sensitivity to A147T translocator protein

The translocator protein (TSPO) is a target for the development of neuroinflammation imaging agents. Clinical translation of TSPO PET ligands, such as [(11)C]DPA-713, has been hampered by the presence of a common polymorphism (A147T TSPO), at which all second-generation TSPO ligands lose affinity. L...

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Udgivet i:RSC Med Chem
Main Authors: Vo, Sophie V., Banister, Samuel D., Freelander, Isaac, Werry, Eryn L., Reekie, Tristan A., Ittner, Lars M., Kassiou, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2020
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489257/
https://ncbi.nlm.nih.gov/pubmed/33479652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00580c
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