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Reversing binding sensitivity to A147T translocator protein
The translocator protein (TSPO) is a target for the development of neuroinflammation imaging agents. Clinical translation of TSPO PET ligands, such as [(11)C]DPA-713, has been hampered by the presence of a common polymorphism (A147T TSPO), at which all second-generation TSPO ligands lose affinity. L...
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| Publicado en: | RSC Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7489257/ https://ncbi.nlm.nih.gov/pubmed/33479652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00580c |
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