Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head Astrocytes

PURPOSE: We determined whether δ-opioid receptor agonist (SNC-121) regulates acetylation homeostasis via controlling histone deacetylases (HDACs) activity and expression in optic nerve head (ONH) astrocytes. METHODS: ONH astrocytes were treated with SNC-121 (1 µM) for 24 hours. The HDAC activity was...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Invest Ophthalmol Vis Sci
Päätekijät: Zaidi, Syed A. H., Thakore, Nakul, Singh, Sudha, Guzman, Wendy, Mehrotra, Shikhar, Gangaraju, Vamsi, Husain, Shahid
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Association for Research in Vision and Ophthalmology 2020
Aiheet:
Physiology and Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488628/
https://ncbi.nlm.nih.gov/pubmed/32915982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.11.17
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