Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Principais autores: Frączek, Karolina, Ferraiolo, Mattia, Hermans, Emmanuel, Bujalska-Zadrozny, Magdalena, Kasarello, Kaja, Erdei, Anna, Kulik, Kamila, Kowalczyk, Agnieszka, Wojciechowski, Piotr, Sulejczak, Dorota, Sosnowski, Piotr, Granica, Sebastian, Benyhe, Sandor, Kaczynska, Katarzyna, Nagraba, Lukasz, Stolarczyk, Artur, Cudnoch-Jedrzejewska, Agnieszka, Kleczkowska, Patrycja
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488486/
https://ncbi.nlm.nih.gov/pubmed/32963942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.04.014
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