Disruption in iron homeostasis and impaired activity of iron-sulfur cluster containing proteins in the yeast model of Shwachman-Diamond syndrome

BACKGROUND: Shwachman-Diamond syndrome (SDS) is a congenital disease that affects the bone marrow, skeletal system, and pancreas. The majority of patients with SDS have mutations in the SBDS gene, involved in ribosome biogenesis as well as other processes. A Saccharomyces cerevisiae model of SDS, la...

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Veröffentlicht in:Cell Biosci
Hauptverfasser: Jain, Ayushi, Nilatawong, Phubed, Mamak, Narinrat, Jensen, Laran T., Jensen, Amornrat Naranuntarat
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488397/
https://ncbi.nlm.nih.gov/pubmed/32944219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-020-00468-2
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