Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer

BACKGROUND: NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown. METHODS: We detected the protein levels of NEK2 in cervical carcinoma tissues and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Xu, Tie, Zeng, Yulan, Shi, Linli, Yang, Qin, Chen, Yeshan, Wu, Gang, Li, Guiling, Xu, Shuangbing
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488040/
https://ncbi.nlm.nih.gov/pubmed/32907622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01659-y
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