A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4(+) T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP). The viral transactivator of the pX region (Tax)...

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Detalles Bibliográficos
Publicado en:Retrovirology
Main Authors: Millen, Sebastian, Meretuk, Lina, Göttlicher, Tim, Schmitt, Sarah, Fleckenstein, Bernhard, Thoma-Kress, Andrea K.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488018/
https://ncbi.nlm.nih.gov/pubmed/32912211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-020-00538-w
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