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Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

BACKGROUND: Motor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases or spinal cord injuries. Being proliferative and located near neurons, astrocytes are considered ideal cell sources for regenerating neurons. METHODS: We selected and tested diff...

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Bibliografske podrobnosti
izdano v:Mil Med Res
Main Authors: Zhao, An-Dong, Qin, Hua, Sun, Meng-Li, Ma, Kui, Fu, Xiao-Bing
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487818/
https://ncbi.nlm.nih.gov/pubmed/32892745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40779-020-00271-7
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