A nicotine-induced positive feedback loop between HIF1A and YAP1 contributes to epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma

BACKGROUND: Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated whether cigarette smoke/nicotine drives EMT in pancreatic ductal adenocarcinoma...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Ben, Qiwen, An, Wei, Sun, Yunwei, Qian, Aihua, Liu, Jun, Zou, Duowu, Yuan, Yaozong
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487530/
https://ncbi.nlm.nih.gov/pubmed/32894161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01689-6
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