Synthesis of 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19 drugs

ABSTRACT: During formylation of 2-quinolones by DMF/Et(3)N mixture, the unexpected 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones) were formed. The discussed mechanism was proved as due to the formation of 4-formyl-2-quinolone as intermediate. Reaction of the latter compound with the parent quinolon...

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Publicado no:Mol Divers
Main Authors: Aly, Ashraf A., Hassan, Alaa A., Mohamed, Asmaa H., Osman, Esraa M., Bräse, Stefan, Nieger, Martin, Ibrahim, Mahmoud A. A., Mostafa, Sara M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7487287/
https://ncbi.nlm.nih.gov/pubmed/32926254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11030-020-10140-z
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