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Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy
Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase (CHST6) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS to precipitate in keratocytes and the corneal stroma. We investigated roles for inflammatory responses in MCD pathogene...
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| Gepubliceerd in: | Cell Death Discov |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7487068/ https://ncbi.nlm.nih.gov/pubmed/32983576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00320-z |
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