Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

Nonshivering thermogenesis occurs in brown adipose tissue to generate heat in response to cold ambient temperatures. Thioesterase superfamily member 1 (Them1) is transcriptionally up-regulated in brown adipose tissue upon exposure to the cold and suppresses thermogenesis in order to conserve energy...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Tillman, Matthew C., Imai, Norihiro, Li, Yue, Khadka, Manoj, Okafor, C. Denise, Juneja, Puneet, Adhiyaman, Akshitha, Hagen, Susan J., Cohen, David E., Ortlund, Eric A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486800/
https://ncbi.nlm.nih.gov/pubmed/32820071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003877117
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