A mutation in POLR3E impairs antiviral immune response and RNA polymerase III

RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I interferons (IFNs). However, the genetic and functional links of Pol III to innate immunity in humans remain l...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ramanathan, Aravind, Weintraub, Michael, Orlovetskie, Natalie, Serruya, Raphael, Mani, Dhivakar, Marcu, Orly, Stepensky, Polina, Weisblum, Yiska, Djian, Esther, Shaag, Avraham, Revel-Vilk, Shoshana, Fried, Iris, Kotler, Moshe, Rouvinski, Alex, Wolf, Dana, Elpeleg, Orly, Jarrous, Nayef
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486780/
https://ncbi.nlm.nih.gov/pubmed/32843346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009947117
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