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Shared structural mechanisms of general anesthetics and benzodiazepines
Most general anesthetics and classical benzodiazepines act through positive modulation of γ-aminobutyric acid type A (GABA(A)) receptors to dampen neuronal activity in the brain(1–5). Direct structural information for how these drugs work at their physiological receptor sites is absent for general a...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7486282/ https://ncbi.nlm.nih.gov/pubmed/32879488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2654-5 |
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