Reduced Platelet miR-223 Induction in Kawasaki Disease Leads To Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis

RATIONALE: Kawasaki disease (KD) is an acute vasculitis of early childhood that can result in permanent coronary artery structural damage. The etiology for this arterial vulnerability in up to 15% of KD patients is unknown. Vascular smooth muscle cell (VSMC) dedifferentiation play a key role in the...

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Publicat a:Circ Res
Autors principals: Zhang, Yuan, Wang, Yanfei, Zhang, Li, Xia, Luoxing, Zheng, Minhui, Zeng, Zhi, Liu, Yingying, Yarovinsky, Timur, Ostriker, Allison C., Fan, Xuejiao, Weng, Kai, Su, Meiling, Huang, Ping, Martin, Kathleen A., Hwa, John, Tang, Wai Ho
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486265/
https://ncbi.nlm.nih.gov/pubmed/32597702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.316951
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