Clostridioides difficile Senses and Hijacks Host Heme for Incorporation into an Oxidative Stress Defense System

Clostridioides difficile infection of the colon leads to severe inflammation and damage to the gastrointestinal epithelium due to the production of potent toxins. This inflammatory tissue damage causes the liberation of high concentrations of host heme at infection sites. Here, we identify the C. di...

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Détails bibliographiques
Publié dans:Cell Host Microbe
Auteurs principaux: Knippel, Reece J., Wexler, Aaron G., Miller, Jeanette M., Beavers, William N., Weiss, Andy, de Crécy-Lagard, Valérie, Edmonds, Katherine A., Giedroc, David P., Skaar, Eric P.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486240/
https://ncbi.nlm.nih.gov/pubmed/32526159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.05.015
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