Nucleolar RNA polymerase II drives ribosome biogenesis

Proteins are universally manufactured by ribosomes, which are assembled within major nuclear compartments called nucleoli(1,2). Current paradigms suggest that only RNA polymerase I and III (Pol I and Pol III) directly mediate the expression of ribosomal RNA (rRNA) components of ribosomes. Here, we s...

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Udgivet i:Nature
Main Authors: Abraham, Karan J., Khosraviani, Negin, Chan, Janet N.Y., Gorthi, Aparna, Samman, Anas, Zhao, Dorothy Y., Wang, Miling, Bokros, Michael, Vidya, Elva, Ostrowski, Lauren A., Oshidari, Roxanne, Pietrobon, Violena, Patel, Parasvi, Algouneh, Arash, Singhania, Rajat, Liu, Yupeng, Yerlici, V. Talya, De Carvalho, Daniel D., Ohh, Michael, Dickson, Brendan C., Hakem, Razq, Greenblatt, Jack F., Lee, Stephen, Bishop, Alexander J. R., Mekhail, Karim
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486236/
https://ncbi.nlm.nih.gov/pubmed/32669707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2497-0
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