Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents

DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability. These lesions also contribute to the efficacy of radiotherapy and many cancer chemotherapeutics. DNA repair efficiency is regulated by both intracellular and extracellular chemical signals. However, it is la...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Deng, Min, Lin, Jing, Nowsheen, Somaira, Liu, Tongzheng, Zhao, Yingchun, Villalta, Peter W., Sicard, Delphine, Tschumperlin, Daniel J., Lee, SeungBaek, Kim, JungJin, Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486107/
https://ncbi.nlm.nih.gov/pubmed/32917705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb2630
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