SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy

Mechanical overloading-induced nucleus pulposus (NP) cells senescence plays an important role in the pathogenesis of intervertebral disc degeneration (IVDD). The silent mating type information regulator 2 homolog-1 (SIRT1)-mediated pathway preserves the normal NP cell phenotype and mitochondrial hom...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Wang, Yiyang, Wang, Haoming, Zhuo, Yunyun, Hu, Yanzhu, Zhang, Zetong, Ye, Jixing, Liu, Liehua, Luo, Lei, Zhao, Chen, Zhou, Qiang, Li, Pei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485741/
https://ncbi.nlm.nih.gov/pubmed/32687063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103587
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