Sorafenib for Patients with Hepatocellular Carcinoma and Child‐Pugh B Liver Cirrhosis: Lessons Learned from a Terminated Study

LESSONS LEARNED: Recruitment of patients with advanced hepatocellular carcinoma and Child‐Pugh B for sorafenib treatment and additional pharmacokinetic studies is challenging. Patients with Child‐Pugh B liver cirrhosis have high rates of cirrhosis‐related adverse events. BACKGROUND: Few data are ava...

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Опубликовано в: :Oncologist
Главные авторы: Labeur, Tim A., Achterbergh, Roos, Takkenberg, Bart, Van Delden, Otto, Mathôt, Ron, Klümpen, Heinz‐Josef
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Inc. 2019
Предметы:
Clinical Trial Results
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485346/
https://ncbi.nlm.nih.gov/pubmed/31645371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0718
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